Objectives The joint effect of shift work and certain adverse life-style factors on coronary heart disease (CHD) was studied.
Methods Base-line measurements were obtained for a 6-year follow-up of an industrially employed cohort (N=1806), whose shiftwork status was recorded from a questionnaire filled out by a sample of the cohort.
The CHD end points (codes 410-414 of the 9th revision of the International Classification of Diseases) were obtained from official Finnish registers.
In order that the joint effects of shift work and life-style factors on the risk of CHD could be studied, dichotomized variables and their combinations as a dummy variable system in Cox's proportional hazards models were used.
Results The relative risks were 1,1.6 [95% confidence interval (95% CI) 1.1-2.5], 1.3 (95% CI 0.9-2.1), and 2.7 (95% CI 1.8-4.1) for the following combinations of shift work (SW) and smoking (SM) : SW- & SM-SW & SM+SW+ & SM-and SW+ & SM+respectively ; and the corresponding figures for shift work and obesity (BMI >=28 kg/m2) were 1,1.2 (95% Cl 0.8-1.9), 1.3 (95% CI 0.9-1.9), and 2.3 (95% CI 1.5-3.6), respectively.
In both cases the effect was at least multiplicative.
For the shift workers the relative risk for CHD rose gradually with increasing numbers of adverse life-style factors, but for the day workers there was no clear dose-response pattern. (...)
Mots-clés Pascal : Travail posté, Médecine travail, Industrie, Cardiopathie coronaire, Facteur risque, Mode de vie, Homme, Rythme circadien, Rythme travail, Corrélation, Obésité, Exercice physique, Tabagisme, Etude cohorte, Etude longitudinale, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Shift work, Occupational medicine, Industry, Coronary heart disease, Risk factor, Life style, Human, Circadian rhythm, Working rhythm, Correlation, Obesity, Physical exercise, Tobacco smoking, Cohort study, Follow up study, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0057423
Code Inist : 002B30B04. Création : 31/05/1999.