Benefit of aggressive lipid-lowering therapy : Insights from the Post Coronary Artery Bypass Graft Study and other trials.
Western Working Group Consensus Conference. Maui, HI, USA, 1997/11/20.
The importance of treating patients to lower cholesterol levels to lessen the risk of developing atherosclerosis is well accepted.
However, the benefits of aggressive treatment for lowering low-density lipoprotein (LDL) cholesterol and a defined threshold at which lowering cholesterol is of little use are still questionable.
Although definitive answers are still not available, interesting data come from follow-ups and reviews of epidemiologic and clinical trials completed decades ago.
In the Seven Countries Study, a 25-year follow-up shows that while absolute levels of coronary artery disease mortality differed by geographic area, the relative increase in mortality due to a given increase in cholesterol was similar in all cultures except Japan.
A new look at the Framingham Study reveals that mean serum cholesterol of persons developing coronary disease has been decreasing progressively for the last 3 decades.
Most recently, average levels of total serum cholesterol and LDL cholesterol for men are below the levels now recommended for treatment according to the National Cholesterol Education Program guidelines.
Clinical and angiographic intervention trials have now ascertained that lowering LDL cholesterol is effective in prevention and in secondary treatment of coronary atherosclerosis. (...)
Mots-clés Pascal : Cardiopathie coronaire, Dérivation, Homogreffe, Cholestérol LDL, Essai thérapeutique contrôlé, Dose forte, Angiographie, Postopératoire, Efficacité traitement, Recommandation, Homme, Epidémiologie, Appareil circulatoire pathologie, Greffe, Radiodiagnostic
Mots-clés Pascal anglais : Coronary heart disease, Bypass, Homograft, Cholesterol LDL, Controlled therapeutic trial, High dose, Angiography, Postoperative, Treatment efficiency, Recommendation, Human, Epidemiology, Cardiovascular disease, Graft, Radiodiagnosis
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0051944
Code Inist : 002B02N. Création : 31/05/1999.