To examine the relationship between modifiable lifestyle factors (smoking, physical activity, alcohol intake, and body mass index [BMI]) and the likelihood of 15-year survival free of major cardiovascular end points and diabetes in middle-aged men.
A prospective study of 7142 men aged 40 to 59 years at screening with no history of coronary heart disease, diabetes, and stroke drawn from 1 general practice in each of 24 British towns and followed up for 15 years.
Death from any cause and a combined end point, including survival free of heart attacks or stroke or the development of diabetes over a follow-up of 15 years for each man.
During the 15-year follow-up, there were 1064 deaths from all causes, 770 major heart attacks (fatal and nonfatal), 247 stroke events (fatal and nonfatal), and 252 cases of diabetes among the 7142 men.
After adjustment for age and each of the other modifiable lifestyle factors, the risk of the combined end point (death or having a heart attack, stroke, or diabetes) went up significantly with increasing smoking levels and from BMI levels of 26 kg/m2 or higher, and decreased significantly with increasing levels of physical activity up to levels of moderate activity with no further benefit thereafter (heavy smoking vs never : relative risk [RR] [odds], 2.50 ; 95% confidence interval [CI], 2.12-2.94 ; BMI >=30 VS 20-21.9 kg/m2 : RR, 2.11 ; 95% CI, 1.71-2.62 ; moderate vs inactive (...)
Mots-clés Pascal : Mode de vie, Dépistage, Modification, Tabagisme, Exercice physique, Indice masse corporelle, Prévention, Long terme, Etude longitudinale, Cardiopathie, Diabète, Age mûr, Angleterre, Grande Bretagne, Royaume Uni, Europe, Homme, Toxicologie, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Life style, Medical screening, Modification, Tobacco smoking, Physical exercise, Body mass index, Prevention, Long term, Follow up study, Heart disease, Diabetes mellitus, Middle age, England, Great Britain, United Kingdom, Europe, Human, Toxicology, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0050579
Code Inist : 002B30A03C. Création : 31/05/1999.