To determine the role of tracheal colonization at birth with Ureaplasma urealyticum and other pathogenic bacteria with regard to the development of bronchopulmonary dysplasia (BPD), 97 premature infants with very low birth weight (<1500 g) were followed prospectively over 30 days in a multicentre study.
Of those infants, 35 were colonized with Ureaplasma urealyticum (group Ia), 22 with other pathogenic bacteria (group Ib) and 40 infants with sterile tracheal aspirates served as controls (group II).
Colonization with Ureaplasma urealyticum or with pathogenic bacteria independently increased the risk of developing BPD as compared to the controls (OR 2.55 ; 95% Cl [1. 11,5.87]). Among Ureaplasma urealyticum and bacterial colonized infants, duration of mechanical ventilation and oxygen requirement were significantly longer than among controls (P<0.05) ; during the interval of I 1 to 35 days of life, every additional day of ventilation significantly increased the risk of BPD (OR 1.22 ; Cl [1.12. 1.32]). The rate of oxygen supplementation, which was similar in both groups during the first 2 weeks of life, was significantly higher among the colonized infants at day 21 (0.38 ± 0.18 and 0.39 ± 0.16 vs 0.31 ± 0.13, P<0.05) and at day 28 (0.38 ± 0.21 and 0.34 ± 0.15 vs 0.28 ± 0.12, P<0.05).
For infants still ventilated at age of 28 days, Ureaplasma urealyticum and bacterial colonization were associated with a significant higher risk for BPD than for uncolonized controls (OR 5. (...)
Mots-clés Pascal : Dysplasie bronchopulmonaire, Association, Colonisation, Ureaplasma urealyticum, Mycoplasmataceae, Mycoplasmatales, Mollicutes, Bactérie, Trachée, Facteur risque, Ventilation mécanique, Durée, Oxygénothérapie, Etude multicentrique, Etude comparative, Prospection, Allemagne, Europe, Morbidité, Etude statistique, Poids naissance très faible, Prématuré, Nouveau né, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Nouveau né pathologie, Infection, Bactériologie, Réanimation respiratoire, Unité soin intensif
Mots-clés Pascal anglais : Bronchopulmonary dysplasia, Association, Colonization, Ureaplasma urealyticum, Mycoplasmataceae, Mycoplasmatales, Mollicutes, Bacteria, Trachea, Risk factor, Mechanical ventilation, Duration, Oxygenotherapy, Multicenter study, Comparative study, Prospecting, Germany, Europe, Morbidity, Statistical study, Very low birthweight, Premature, Newborn, Human, Respiratory disease, Lung disease, Bronchus disease, Newborn diseases, Infection, Bacteriology, Respiratory intensive care, Intensive care unit
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0050291
Code Inist : 002B27B11. Création : 31/05/1999.