Background Respiratory tract viral infections (RTVls) have been identified frequently in association with asthma exacerbations in children, but few studies have shown similar rates of viral infections in adults with asthma.
Further studies using newer diagnostic techniques to evaluate the frequency of RTVIs in adults with acute exacerbations of asthma need to be performed.
Twenty-nine asthmatic adults were recruited from the pulmonary clinic of an urban county hospital and were followed up in a longitudinal cohort study for signs and symptoms of asthma and RTVI.
One hundred twenty-two asthmatic adults presenting to the emergency department (ED) of the same hospital with acute symptoms of asthma underwent evaluation for RTVI in a cross-sectional prevalence study.
In both studies, respiratory secretions and paired serum samples were collected from subjects with acute wheezing episodes and evaluated using virus culture, serologic testing, and reverse transcription-polymerase chain reaction (RT-PCR).
In the longitudinal cohort study, 138 respiratory illnesses, of which 87 were asthma exacerbations, were evaluated ; 41% of all illnesses and 44% of asthma exacerbations were associated with an RTVI.
In the ED study, 148 asthma exacerbations were evaluated ; 55% were associated with an RTVI.
An RTVI was identified in 21 (50%) of 42 of the subjects hospitalized in the ED study. (...)
Mots-clés Pascal : Virose, Infection, Appareil respiratoire, Complication, Asthme, Etude cohorte, Zone urbaine, Transcription inverse, Réaction chaîne polymérase, Sérologie, Evaluation, Prévalence, Diagnostic, Adulte, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Biologie moléculaire
Mots-clés Pascal anglais : Viral disease, Infection, Respiratory system, Complication, Asthma, Cohort study, Urban area, Reverse transcription, Polymerase chain reaction, Serology, Evaluation, Prevalence, Diagnosis, Adult, Human, United States, North America, America, Respiratory disease, Obstructive pulmonary disease, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0049384
Code Inist : 002B05C02C. Création : 31/05/1999.