This article uses meta-analysis methodology to examine the statistical consistency and importance of random variation among results of epidemiologic studies of residential magnetic field exposure and childhood leukemia.
A variety of meta-analytic statistical methods were applied to all available studies combined and on subgroups of studies chosen by exposure characteristics.
Sample sizes and failsafe n's were calculated to determine the robustness of results and the potential role of publication bias.
Most studies show elevated but not statistically significant odds ratios.
Results for exposures assessed by wire codes, distance, and/or historically reconstructed fields are relatively consistent, homogeneous, and positive, while those for direct magnetic field measurements are consistent, homogeneous, and marginally protective.
Several unpublished studies, or a single unpublished study with several hundred subjects, would be needed to nullify the observed data.
The observed results identify a consistent risk that cannot be explained by random variation.
The data supporting magnetic fields as the principal risk factor are suggestive but inconsistent.
Additional studies using innovative designs that focus on highly exposed children offer the most hope of untangling this issue.
Mots-clés Pascal : Leucémie, Champ électromagnétique, Exposition, Santé et environnement, Logement habitation, Epidémiologie, Facteur risque, Enfant, Homme, Métaanalyse, Hémopathie maligne
Mots-clés Pascal anglais : Leukemia, Electromagnetic field, Exposure, Health and environment, Housing, Epidemiology, Risk factor, Child, Human, Metaanalysis, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0048937
Code Inist : 002B19B. Création : 31/05/1999.