A population-based sample of acute childhood leukaemia cases in Sweden 1973-94 was analysed by a geographical information system (GIS) for spatial leukaemia distribution in relation to population density.
The annual incidence rate for acute lymphoblastic leukaemia (ALL) was 3.6, and for acute non-lymphoblastic leukaemia (ANLL) 0.7, cases per 100 000 children.
Incidence rates in population centres, constituting 1.3% of Sweden's land area and approximately 80% of the population, compared with the rest of Sweden showed a statistically significant excess of ALL [odds ratio (OR) 1.68 ; 95% confidence interval (Cl) 1.44-1.95], but not ANLL (OR 1.13 ; 95% Cl 0.98-1.32).
An increasing trend, however not statistically significant, was found for ALL incidence with both increasing population density in parishes and increasing degree of urbanity in municipalities.
These findings support the theories that some environmental factors associated with high population density, such as infectious agents, may be of aetiological importance for childhood acute lymphoblastic leukaemia.
Mots-clés Pascal : Leucémie lymphoblastique, Facteur risque, Incidence, Epidémiologie, Densité population, Infection, Assistance ordinateur, Suède, Europe, Enfant, Homme, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Risk factor, Incidence, Epidemiology, Population density, Infection, Computer aid, Sweden, Europe, Child, Human, Acute, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0047165
Code Inist : 002B19B. Création : 31/05/1999.