A molecular epidemiology study in women from Upper Silesia, Poland.
European Meeting of Environmental Hygiene. Graz, ATR, 1997/06/03.
The present report is a follow-up to our previous molecular epidemiology studies on DNA damage in residents of the industrial region of Upper Silesia.
The study was designed to focus on environmental exposure to airborne pollutants : other exposures or confounding factors (e.g. smoking status and age) were eliminated.
A Silesian population consisting of 67 donors was compared to 72 inhabitants of a less polluted but similarly urbanized area, surrounded by a rural part of Poland.
In both regions the donors were non-smoking females with similar age range. and occupation.
Eight biomarkers including urinary mutagenicity and 1-hydroxypyrene, polycylic aromatic hydrocarbon PAH-DNA adducts in oral mucosa, sister chromatid exchanges (SCE), high frequency cells (HFC), chromosomal aberrations (CA), and sensitivity to bleomycin in lymphocytes as well as glutathione s-transferase (GSTM1)/cytochrome P4501A1 (CYP1A1) genotypes were evaluated in samples collected in summer and winter seasons.
All the biomarkers of internal and biological doses of mutagens and their early biologic effects indicated statistically significant increases in the Silesian group when compared to the controls.
Immunohistochemical quantitation of PAH-DNA adducts additionally revealed significant seasonal changes in the levels of adducts.
No influence of susceptibility genotypes (GSTM1 and CYP1A1) on biomarker levels was observed.
Mots-clés Pascal : Epidémiologie, Surveillance biologique, Toxicité, Mutagène, Carcinogène, Pollution air, Composé aromatique polycyclique, DNA, Pologne, Europe, Zone urbaine, Zone industrielle, Marqueur biologique, Test mutagénicité, Aberration chromosomique, Femme, Homme, Variation saisonnière, Evaluation risque
Mots-clés Pascal anglais : Epidemiology, Biological monitoring, Toxicity, Mutagen, Carcinogen, Air pollution, Polycyclic aromatic compound, DNA, Poland, Europe, Urban area, Industrial area, Biological marker, Mutagenicity testing, Chromosomal aberration, Woman, Human, Seasonal variation, Risk assessment
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0046467
Code Inist : 002B03N. Création : 31/05/1999.