Risk of non-Hodgkin's lymphoma in patients with hepatitis C virus infection.
Hepatitis C virus (HCV) has been suggested to play an etiological role in the development of B-cell non-Hodgkin's lymphoma (NHL) in Italy.
However, another study in Scotland questioned increased risk of development of NHL in patients with chronic HCV infection.
A total of 2,162 patients admitted to 3 hospitals in Osaka, where the incidence of HCV-related hepatitis is highest in Japan, during the period from 1957 to 1997 were followed up from the date of diagnosis of chronic HCV-related hepatitis until 30 October 1997.
Overall, 12,404.5 person-years of observation were accrued with a follow-up period ranging from 0.25 to 40.4 (average 5.74) years.
NHL of the B-cell type developed in 4 patients.
The interval between onset of chronic HCV and NHL ranged from 6 to 36 (median 13) years.
Expected number of cases of NHL in the sex-age-and calender year-matched general population was 1.90, which gave a relative risk (RR) of 2.10 (95% confidence interval 0.57-5.38 ; p=0.247).
Taking the much higher RR for hepatocellular carcinoma among patients with HCV infection into account, chronic HCV infection was considered to be moderately associated with increased risk of NHL.
Mots-clés Pascal : Lymphome non hodgkinien, Facteur risque, Epidémiologie, Hépatite virale C, Virose, Infection, Etude cohorte, Japon, Asie, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Risk factor, Epidemiology, Viral hepatitis C, Viral disease, Infection, Cohort study, Japan, Asia, Human, Malignant hemopathy, Lymphoproliferative syndrome, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0046038
Code Inist : 002B19B. Création : 31/05/1999.