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  1. Risk of non-Hodgkin's lymphoma in patients with hepatitis C virus infection.

    Article - En anglais

    Hepatitis C virus (HCV) has been suggested to play an etiological role in the development of B-cell non-Hodgkin's lymphoma (NHL) in Italy.

    However, another study in Scotland questioned increased risk of development of NHL in patients with chronic HCV infection.

    A total of 2,162 patients admitted to 3 hospitals in Osaka, where the incidence of HCV-related hepatitis is highest in Japan, during the period from 1957 to 1997 were followed up from the date of diagnosis of chronic HCV-related hepatitis until 30 October 1997.

    Overall, 12,404.5 person-years of observation were accrued with a follow-up period ranging from 0.25 to 40.4 (average 5.74) years.

    NHL of the B-cell type developed in 4 patients.

    The interval between onset of chronic HCV and NHL ranged from 6 to 36 (median 13) years.

    Expected number of cases of NHL in the sex-age-and calender year-matched general population was 1.90, which gave a relative risk (RR) of 2.10 (95% confidence interval 0.57-5.38 ; p=0.247).

    Taking the much higher RR for hepatocellular carcinoma among patients with HCV infection into account, chronic HCV infection was considered to be moderately associated with increased risk of NHL.

    Mots-clés Pascal : Lymphome non hodgkinien, Facteur risque, Epidémiologie, Hépatite virale C, Virose, Infection, Etude cohorte, Japon, Asie, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Non Hodgkin lymphoma, Risk factor, Epidemiology, Viral hepatitis C, Viral disease, Infection, Cohort study, Japan, Asia, Human, Malignant hemopathy, Lymphoproliferative syndrome, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0046038

    Code Inist : 002B19B. Création : 31/05/1999.