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  1. Measles infection, measles vaccination and the effect of birth order in the aetiology of hay fever.

    Article - En anglais

    Background It has recently been suggested that measles infection may reduce the risk of atopy.

    Objective To study the independent effect of measles infection and measles vaccination on the occurrence of hay fever in a British national birth cohort.

    Methods In over 6000 children born in 1970, details of immunizations and childhood diseases were collected by parental interviews at ages 5,10 and 16 years, and hay fever within the past year at age 16 years.

    Results In univariate analysis, hay fever was less common in those contracting measles infection than in those not infected (OR 0.86,95% CI 0.76-0.96), and more common in those given measles vaccination than in those not vaccinated (OR 1.16,95% CI 1.03-1.31).

    However, these effects were strongly confounded by birth order, which was closely associated with the likelihood of receiving measles vaccination and with the risk of hay fever.

    A strong interaction between the effects of measles vaccination and infection, and birth order was found, such that in those with many older sibling contacts, hay fever was significantly and independently reduced in relation to both measles infection and measles vaccination relative to those who were neither infected nor vaccinated.

    Conclusions Both measles infection and measles vaccination in childhood appear to reduce the risk of hay fever in children with multiple older sibling contacts. (...)

    Mots-clés Pascal : Rhinite, Allergie, Enfant, Homme, Rougeole, Virose, Infection, Vaccination, Rang naissance, Facteur risque, Etude statistique, Etude cohorte, Royaume Uni, Europe, Epidémiologie, ORL pathologie, Nez pathologie, Immunopathologie

    Mots-clés Pascal anglais : Rhinitis, Allergy, Child, Human, Measles, Viral disease, Infection, Vaccination, Birth order, Risk factor, Statistical study, Cohort study, United Kingdom, Europe, Epidemiology, ENT disease, Nose disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0045702

    Code Inist : 002B06C02. Création : 31/05/1999.