Zur Frage der Atiologie von Nasentumoren in der Holzwirtschaft.
Traduction en anglais : Etiology of nose cancer in the wood working industry.
To be able to distinguish the role of natural oak and beech wood dust in the development of adenocarcinoma of the nose from that of additives such as lacquers, solvents, glues or wood-preservatives a) functional and morphological modifications of the mucous membranes of the nose after defined occupational exposure were recorded for 149 exposed workers and 33 controls, b) the quantity and quality of workplace exposure was determined by way of concentration measurements and chemical analyses carried out on 614 wood dust samples, c) the genotoxic effect of the most frequently found substances in the wood working industry was examined, d) the development of latency and incidence in connection with adenocarcinoma of the nose in Germany were investigated, e) the results were used to realise long-term inhalation tests on female rats.
Hypoplasia of the cylindrical cells turned out to be the most frequently found morphological changes of the nasal mucous membranes following exposure to wood dust.
The effect was even stronger after additional exposure to solvents.
Dysplasia were more observed when wood preservatives were found.
In 73% of the 614 samples wood preservations could be analysed.
A genotoxic effect could be shown especially for oak wood, to a smaller extent for beech wood and to no extent at all for softwood.
These findings comply with the epidemiological data.
The genotoxocity of Lindan and PCP in nose cells of rats and humans is a proven fact. (...)
Mots-clés Pascal : Industrie bois, Exposition professionnelle, Médecine travail, Tumeur maligne, Nez, Etiologie, Bois, Composé chimique, Epidémiologie, Allemagne, Europe, Homme, Rat, Rodentia, Mammalia, Vertebrata, Animal, Inhalation, Agent préservation bois, Toxicité, Histopathologie, ORL pathologie, Nez pathologie
Mots-clés Pascal anglais : Wood industry, Occupational exposure, Occupational medicine, Malignant tumor, Nose, Etiology, Wood, Chemical compound, Epidemiology, Germany, Europe, Human, Rat, Rodentia, Mammalia, Vertebrata, Animal, Inhalation, Wood preservative, Toxicity, Histopathology, ENT disease, Nose disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0044019
Code Inist : 002B10B01. Création : 31/05/1999.