A group of 102 Mexican Mestizo patients with appropriate clinical features suggestive of primary thrombophilia was prospectively studied.
Thirty-nine percent of them had activated protein C resistance, but only four patients displayed the factor V Leiden mutation.
Five percent of the individuals were found to be protein C deficient, whereas 2% had protein S deficiency.
No cases of abnormalities in antithrombin III, plasminogen, tissue-type plasminogen activator or plasminogen activator inhibitor were found.
The low prevalence of the activated protein C resistance genotype, probably stemming from the genetic admixture of the Mexican Mestizo group is noteworthy.
Mots-clés Pascal : Hypercoagulabilité, Résistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Facteur V Leiden, Complication, Thrombose, Prévalence, Epidémiologie, Mexique, Amérique Centrale, Amérique, Prospective, Homme, Hémopathie, Coagulopathie, Maladie héréditaire, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Hypercoagulability, Resistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Factor V Leiden, Complication, Thrombosis, Prevalence, Epidemiology, Mexico, Central America, America, Prospective, Human, Hemopathy, Coagulopathy, Genetic disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0043578
Code Inist : 002B19C. Création : 31/05/1999.