A recent report in the literature suggested a link between occupational exposure to lead and brain cancer.
To explore the hypothesis, we applied a job-exposure matrix for lead to the occupation and industry codes given on the death certificate of 27,060 brain cancer cases and 108,240 controls who died of non-malignant diseases in 24 US states in 1984-1992.
Brain cancer risk increased by probability of exposure to lead among Caucasian men and women with high-level exposure, with a significant twofold excess among Caucasian men with high probability and high level ofexposure to lead (odds ratio=2.1 ; 95% confidence interval, 1.1-4.0).
Risks were also elevated in the low and medium-probability cells for African-American men with high-level exposure to lead.
Trend by intensity level was statistically significant among African-American men (all probabilities combined).
Although exposure assessment was based solely on the occupation and industry reported on the death certificate, these results add to other epidemiologic and experimental findings in lending some support to the hypothesis of an association between occupational exposure to lead and brain cancer risk.
Analytic studies are warranted to further test this hypothesis.
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Plomb, Tumeur maligne, Intracrânien, Métal lourd, Homme, Industrie, Certificat décès, Recherche rétrospective, Facteur risque, Comparaison interindividuelle, Race, Profession, Analyse statistique, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Lead, Malignant tumor, Intracranial, Heavy metal, Human, Industry, Death certificate, Retrospective searching, Risk factor, Interindividual comparison, Race, Profession, Statistical analysis, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0041598
Code Inist : 002B17E. Création : 31/05/1999.