Prognosis of chronic hepatitis C : Results of a large, prospective cohort study.
The prognosis of chronic hepatitis C virus (HCV) infection is still ill-defined.
The present study prospectively evaluated mortality and complications in a large cohort of patients with chronic hepatitis C. The study included 838 anti-HCV and HCV-RNA-positive patients who were followed for 50.2 ± 26.9 months (mean ± SD ; range, 6-122 months) in a prospective protocol.
During follow-up, 62 patients died (31 from liver disease and 31 from other causes), and 12 patients needed liver transplantation.
When compared with a matched general population, hepatitis C increased mortality mainly when cirrhosis was present and in patients who were less than 50 years old at study entry.
During follow-up, a further 30 patients developed nonlethal complications of cirrhosis.
By multivariate regression, survival was decreased by cirrhosis, long disease duration, history of intravenous drug abuse, and excessive alcohol consumption, whereas interferon therapy improved survival.
Alanine transaminase (ALT), bilirubin, sex, and genotype had no effect on survival.
The risk of hepatocellular carcinoma (HCC) (n=17) was increased by cirrhosis and to a lesser degree by long disease duration and high bilirubin, whereas interferon therapy, genotype, and other factors had no effect.
Chronic hepatitis C is a disease with considerable mortality and morbidity when cirrhosis is present at diagnosis. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Chronique, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Evolution, Mortalité, Facteur prédictif, Pronostic, Complication, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Chronic, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Evolution, Mortality, Predictive factor, Prognosis, Complication, Epidemiology, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0039940
Code Inist : 002B05C02G. Création : 31/05/1999.