A case-control study was conducted to determine whether menstrual and gynecologic abnormalities precede the onset of chronic fatigue syndrome (CFS) in women with this disorder to a greater extent than that observed among healthy controls.
We identified 150 women who met the 1988 Centers for Disease Control criteria for CFS from the Brigham and Women's Hospital Cooperative CFS Research Center.
A comparison group of 149 women being seen for non-gynecologic conditions were selected from the waiting area of the Brigham and Women's Hospital Internal Medicine outpatient department.
Women with and without CFS completed self-administered questionnaires on menstrual, reproductive, and medical history.
Women with CFS reported increased gynecologic complications and a lower incidence of premenstrual symptomatology.
After adjustment for age, a somewhat greater number of cases compared with controls self-reported irregular cycles, periods of amenorrhea, and sporadic bleeding between menstrual periods.
Factors suggestive of abnormal ovarian function-such as a history of polycystic ovarian syndrome, hirsutism, and ovarian cysts-were reported more often in CFS cases compared with controls.
Frequent anovulatory cycles due to ovarian hyperandrogenism (PCOS) or hyperprolactinemia may increase risk for CFS through loss of the potential immunomodulatory effects of progesterone in the presence of continued estrogen production. (...)
Mots-clés Pascal : Fatigue chronique syndrome, Etude cas témoin, Evaluation, Cycle menstruel, Gynécologie, Trouble fonctionnel, Facteur risque, Femelle, Homme, Système nerveux pathologie, Cycle menstruel pathologie
Mots-clés Pascal anglais : Chronic fatigue syndrome, Case control study, Evaluation, Menstrual cycle, Gynecology, Dysfunction, Risk factor, Female, Human, Nervous system diseases, Menstruation disorders
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0039908
Code Inist : 002B17I. Création : 31/05/1999.