Long-term survival and cardiovascular complications in patients with acromegaly and pituitary gigantism.
Novo Nordisk hGH Symposium. Lyon, FRA, 1998/04/23.
Acromegaly results from the chronic hypersecretion of growth hormone (GH) by a pituitary adenoma.
It is an uncommon disease and is associated with decreased life expectancy.
To determine the major factors contributing to the prognosis of acromegaly, we analysed the long-term survival and cardiovascular complications in acromegalic patients who had registered in two nationwide Japanese surveys of hypothalamo-pituitary diseases in 1988 and 1993.
In the 1988 survey, 979 cases of acromegaly and 34 of pituitary gigantism were registered, together with 84 deaths associated with acromegaly (mean age 59.0 years, a decade shorter than that of the general population).
The major causes of death were malignancy (30%), cerebrovascular disease (24%), cardiac disease (21%) and respiratory infection (13%). The overall long-term survival rate of acromegaly cases 20 years after diagnosis was calculated to be 65%. The 1993 survey registered 815 cases of acromegaly and 28 of pituitary gigantism.
In the 5 years since the previous survey, 15 patients had died.
Major complications associated with acromegaly were diabetes mellitus (33%), hypertension (26%), hyperlipidaemia (5.8%), cerebrovascular disease (3.9%) and cardiovascular disease (3.1%). We conclude that chronic GH excess is associated with increased mortality and morbidity due to cardiac and vascular diseases.
Mots-clés Pascal : Acromégalie, Gigantisme, Epidémiologie, Mortalité, Morbidité, Appareil circulatoire pathologie, Complication, Japon, Asie, Homme, Endocrinopathie, Hypophyse pathologie, Système ostéoarticulaire pathologie
Mots-clés Pascal anglais : Acromegaly, Gigantism, Epidemiology, Mortality, Morbidity, Cardiovascular disease, Complication, Japan, Asia, Human, Endocrinopathy, Pituitary diseases, Diseases of the osteoarticular system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0037567
Code Inist : 002B30A01A2. Création : 31/05/1999.