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  1. Tobacco, occupation and non-transitional-cell carcinoma of the bladder : An international case-control study.

    Article - En anglais

    Transitional-cell carcinoma is the dominant histological type of malignant tumors of the urinary bladder.

    There is limited information on risk factors for non-transitional-cell carcinoma (NTCC) of the bladder.

    We used data from 9 case-control studies on bladder cancer from 6 European countries to examine the association between NTCC, tobacco smoking and occupation.

    Information on 146 cases diagnosed with NTCC were matched by age, gender and study center to 727 non-cancer population or hospital controls and also with 722 transitional-cell-bladder-cancer controls.

    Lifetime smoking and occupational history were evaluated.

    A statistically significant excess risk for NTCC was observed for current smoking [odds ratio (OR)=3.61,95% confidence interval (Cl) 2.08-6.28]. The risk increased with higher tobacco consumption (OR for highest tertile of pack-years=7.01,95% Cl 3.60-13.66).

    The risks were higher for squamous-cell carcinomas than for other types of NTCC.

    Among major occupational groups, a significant excess risk was seen for field-crop and vegetable-farm workers (OR=2.06,95% Cl 1.03-4.10).

    These results indicate that NTCC of the bladder is associated with smoking and specific occupations.

    The risk pattern seems to differ, in part, from that observed for transitional-cell carcinoma of the bladder.

    Mots-clés Pascal : Carcinome, Vessie urinaire, Facteur risque, Epidémiologie, Tabagisme, Profession, Etude cas témoin, Europe, Homme, Tumeur maligne, Appareil urinaire pathologie, Voie urinaire pathologie, Vessie pathologie, Carcinome non cellule transitionnelle

    Mots-clés Pascal anglais : Carcinoma, Urinary bladder, Risk factor, Epidemiology, Tobacco smoking, Profession, Case control study, Europe, Human, Malignant tumor, Urinary system disease, Urinary tract disease, Bladder disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0035594

    Code Inist : 002B14D02. Création : 31/05/1999.