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  1. New DNA polymorphisms of human MMH/OGG1 gene : Prevalence of one polymorphism among lung-adenocarcinoma patients in Japanese.

    Article - En anglais

    MMH/OGGI is an 8-hydroxyguanine-specific DNA glycosylaselAP-lyase, one of the mutator enzymes for the excision repair of 8-hydroxyguanine.

    DNA polymorphisms in human MMH/OGGI gene were newly identified and analyzed to examine a possible association with lung-cancer risk by a population-based study.

    Polymorphic allele 3 in hMMH/OGG1 exon I was significantly prevalent among Japanese patients with adenocarcinoma of the lung [odds ratio (OR) : 3.152,95% confidence interval (Cl) : 1.266-7.845], indicating that the excision repair of 8-hydroxyguanine may play a role in predisposition to lung cancer.

    Mots-clés Pascal : Adénocarcinome, Bronchopulmonaire, Facteur risque, Epidémiologie, Variabilité génétique, DNA-(apurinic or apyrimidinic site) lyase, Carbon-oxygen lyases, Lyases, Enzyme, Prévalence, Japon, Asie, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne, Génétique, Gène MMH/OGG1

    Mots-clés Pascal anglais : Adenocarcinoma, Bronchopulmonary, Risk factor, Epidemiology, Genetic variability, DNA-(apurinic or apyrimidinic site) lyase, Carbon-oxygen lyases, Lyases, Enzyme, Prevalence, Japan, Asia, Human, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0034701

    Code Inist : 002B11A. Création : 31/05/1999.