N-acetyl transferase 2 genotypes, meat intake and breast cancer risk.
Heterocyclic amines (HAS) are carcinogens produced by high-temperature cooking of meat and animal protein ; metabolism of HA is influenced by polymorphisms in the N-acetyltransferase-2 (NAT-2) gene.
Data from a variety of sources suggest that HA may play a role in human carcinogenesis.
We examined the associations between meat intake and cooking method, acetylator genotype and breast cancer risk in a sub-cohort of 32,826 women in the Nurses'Health Study who gave a blood sample in 1989-1990.
Women who were diagnosed with breast cancer (n=466) after blood draw and prior to June I, 1994, were matched to 466 controls.
Overall, rapid acetylators were not at increased risk of breast cancer compared with slow acetylators (multivariate OR=1.1,95% Cl 0.8-1.5), and there were no associations between meat intake or cooking method of meat and breast cancer risk.
Rapid acetylators with the highest red meat intake (one or more servings per day) were not at increased risk of breast cancer compared with slow acetylators with the lowest red meat intake (OR=1.1,95% Cl 0.7-1.8).
Frequent intake of charred meat among rapid acetylators (one or more times per week) was not associated with increased risk (OR=1.2,95% Cl 0.6-2.3) compared with slow acetylators who ate charred meat less than once per month.
We observed no significant associations for rapid acetylators who frequently consumed beef, pork or lamb cooked with high-temperature cooking methods, such as barbecuing (OR=0.9,95%). (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Viande, Cuisson, Méthode, Génotype, Variabilité génétique, Amine, Hétérocycle, Carcinogène, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Homme, Glande mammaire pathologie, Génétique, Acyltransferases, Transferases, Enzyme, N-Acetyltransferase-2
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Meat, Cooking, Method, Genotype, Genetic variability, Amine, Heterocyclic compound, Carcinogen, Case control study, United States, North America, America, Human, Mammary gland diseases, Genetics, Acyltransferases, Transferases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0034700
Code Inist : 002B20E02. Création : 31/05/1999.