To study the prevalence of Cervical Intraepithelial Neoplasia (CIN) and its association with HIV-infection, controlling for other risk factors of CIN.
HIV-seropositive (HIV+) and seronegative (HIV-) women were enrolled at the Obstetrics-Gynecologic Departments of the Bordeaux University Hospital from April 1993 to June 1995.
A gynecologic check-up was performed with a clinical examination, a colposcopy and a Papanicolaou smear.
Sexually Transmitted Diseases (STDs) were screened.
Colposcopy was interpreted as : normal, low-grade or high-grade lesions.
Interpretation of Papanicolaou smears was based on the 1988 Bethesda system using three descriptive diagnoses : normal, low-grade and high-grade Squamous Intraepithelial lesions (SILs).
If colposcopy showed a high grade lesion or Papanicolaou smear a high-grade SIL, a cervical biopsy was performed.
Absence of CIN was defined by normal Papanicolaou smear and colposcopy.
High grade CIN was defined by either identification of high grade SIL on Papanicolaou smear or high grade lesion on colposcopy confirmed by CIN2-3 lesion on biopsy.
Other cases were classified as low-grade CIN.
HPV infection was diagnosed on presence of koilocytosis on cytological or histological specimens.
Prevalence of CIN was significantly higher in the 128 HIV+women than in the 102 HIV-women : 34.4% vs. 13.7% (O.R.=3.30).
Among HIV+women, 25.8% had low-grade CIN and 8. (...)
Mots-clés Pascal : Dysplasie col utérus, SIDA, Virose, Infection, Maladie sexuellement transmissible, Epidémiologie, Prévalence, Facteur risque, Homme, Femelle, Lésion précancéreuse, Appareil génital femelle pathologie, Col utérus pathologie, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Cervical dysplasia, AIDS, Viral disease, Infection, Sexually transmitted disease, Epidemiology, Prevalence, Risk factor, Human, Female, Premalignant lesion, Female genital diseases, Uterine cervix diseases, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0033822
Code Inist : 002B05C02D. Création : 31/05/1999.