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  1. A nationwide prospective surveillance study in Israel to document pediatric invasive infections, with an emphasis on Haemophilus influenzae type b infections.

    Article, Communication - En anglais

    International Conference on Haemophilus influenzae type b infection in Asia. Bali, IDN, 1996/12/17.

    Background and methods

    An ongoing nationwide prospective surveillance study was initiated in Israel in October, 1988, to document childhood invasive infections caused by Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis.

    This study enabled us to document the effect on childhood invasive Hib disease of the introduction of conjugate Hib vaccines to Israel.


    The incidence of invasive Hib disease before the age of 5 years dropped from 34 per 100 000 before initiation of immunization to<5 per 100 000 in 1995 and is projected to be<4 in 1996.

    After<2 years, when various conjugate vaccines had been available in the private sector alone and had achieved partial coverage only, the Israeli Ministry of Health decided to add Hib conjugate vaccine to the regular infant immunization program, free of charge, effective for all infants born after January 1,1994.

    The vaccine chosen was Hib polysaccharide linked to outer membrane protein complex of N. meningitidis B. Vaccine coverage has exceeded 90% of all infants born since January 1,1994.

    Efficacy and effectiveness during the first 34 months of the program (January 1,1994, to October 31,1996) were 95.4 and 99.7%, respectively, for all invasive Hib disease and 97 and 99.4%, respectively, for Hib meningitis. (...)

    Mots-clés Pascal : Bactériose, Infection, Haemophilus influenzae, Pasteurellaceae, Bactérie, Prévention, Vaccination, Efficacité, Surveillance, Population, Immunoprophylaxie, Programme sanitaire, Neisseria meningitidis, Neisseriaceae, Micrococcales, Association, Septicémie, Méningite, Analyse avantage coût, Nourrisson, Homme, Enfant, Israël, Asie, Système nerveux pathologie, Système nerveux central pathologie

    Mots-clés Pascal anglais : Bacteriosis, Infection, Haemophilus influenzae, Pasteurellaceae, Bacteria, Prevention, Vaccination, Efficiency, Surveillance, Population, Immunoprophylaxis, Sanitary program, Neisseria meningitidis, Neisseriaceae, Micrococcales, Association, Septicemia, Meningitis, Cost benefit analysis, Infant, Human, Child, Israel, Asia, Nervous system diseases, Central nervous system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0033216

    Code Inist : 002B05A02. Création : 31/05/1999.