To examine if chelated lead was a more predictive indicator of the subclinical effect of lead on conduction velocities of faster or slower nerve fibers as compared with blood lead (BPb).
Distribution of conduction velocities (DCV) in large myelinated fibers of the sensory median nerve was measured twice at a 1-year interval in 17 male gun-metal foundry workers with BPb concentrations of 22-59 (mean 40.2) mug/dl and a mobilization yield of lead into urine (MPb) by calcium disodium ethylenediaminetetraacetate of 0.15-2.09 (mean 1.19) mg/24 h for the lst year and in 20 healthy males (controls).
Yearly changes in the conduction velocities of faster fibers were significantly correlated with the corresponding change in MPb (P<0.05) but not with that in BPb (P>0.05).
In ten workers showing an increase in MPb during the 1-year period (0.44 mg/24 h on average) the conduction velocities of faster fibers were decreased significantly, resulting in the values being significantly lower in all the workers combined than in the controls (P<0.05).
On the other hand, in the remaining workers, who showed a lesser extent of reduction in MPb (0.08 mg/24 h on average), the DCV did not change (P>0.05).
Chelated lead might be a more predictive indicator of the effect of lead on the conduction velocities of faster fibers than blood lead.
Mots-clés Pascal : Plomb, Calcium édétate de sodium, Métal lourd, Industrie fonderie, Nerf périphérique pathologie, Toxicité, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Marqueur biologique, EDTA, Urine, Chélateur, Liquide biologique, Valeur prédictive, Vitesse conduction, Fibre nerveuse, Système nerveux pathologie
Mots-clés Pascal anglais : Lead, Sodium calcium edetate, Heavy metal, Foundry industry, Peripheral nerve disease, Toxicity, Occupational exposure, Occupational medicine, Human, Biological monitoring, Biological marker, EDTA, Urine, Chelating agent, Biological fluid, Predictive value, Conduction velocity, Nerve fiber, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0032406
Code Inist : 002B03L05. Création : 31/05/1999.