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  1. Need for Haemophilus influenzae type b vaccination in Asia as evidenced by epidemiology of bacterial meningitis.

    Article, Communication - En anglais

    International Conference on Haemophilus influenzae type b infection in Asia. Bali, IDN, 1996/12/17.


    To evaluate the role of Haemophilus influenzae type b (Hib) infections in Asia by scrutinizing data on Hib meningitis.


    A comprehensive literature search was performed in English and other languages.

    Special attention was paid to the age group of 0 to 4 years, in which the great majority of Hib meningitis occurs.


    Twenty studies from as many countries indicated Hib to be a major pathogen in childhood meningitis.

    In series comprising nearly 2000 patients, Hib was responsible for at least 50% of cases in one-third of series and for at least 25% in three-fourths of series investigated and was the leading pathogen overall.

    The countries in South and Southeast Asia differed from the Middle East and East Asia in having a greater incidence of meningitis during the first 6 months of life ; the proportions were 50 to 60% vs. 10 to 30%, respectively (P<0.001).


    Despite lacking data from many areas, belief in a paucity of Hib disease in Asia is not supported by the existing data ; and because meningitis represents only 50 to 75% of all classical Hib manifestations and some cases occur after the age of 4 years, vaccination is warranted.

    The cumulative age curves suggest that conjugates with good immunogenic potential should be used, especially in South and Southeast Asia.

    Mots-clés Pascal : Méningite, Bactériose, Infection, Haemophilus influenzae, Pasteurellaceae, Bactérie, Epidémiologie, Revue bibliographique, Etiologie, Age, Mortalité, Séquelle, Complication, Asie, Nourrisson, Homme, Enfant, Système nerveux pathologie, Système nerveux central pathologie, Haemophilus influenzae type b

    Mots-clés Pascal anglais : Meningitis, Bacteriosis, Infection, Haemophilus influenzae, Pasteurellaceae, Bacteria, Epidemiology, Bibliographic review, Etiology, Age, Mortality, Sequela, Complication, Asia, Infant, Human, Child, Nervous system diseases, Central nervous system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0032268

    Code Inist : 002B05B02I. Création : 31/05/1999.