International Conference on Haemophilus influenzae type b infection in Asia. Bali, IDN, 1996/12/17.
A 5-year territory-wide retrospective survey of invasive Haemophilus influenzae type b (Hib) diseases in Hong Kong established that the annual incidence for children<5 years old was 2.7 per 100 000 [95% confidence interval (CI), 2.0 to 3.5]. However, the corresponding annual incidence in Vietnamese refugees in Hong Kong was 42.7 per 100 000 (95% CI 17.2 to 87.9), giving a relative risk of 18.5 (95% CI 8.3 to 41.0).
The nasopharyngeal carriage rate of Hib was zero in 621 healthy Chinese children and 1.3% (95% CI 0.04 to 2.63%) in 300 healthy Vietnamese refugees 2 months to 5 years old in Hong Kong.
The corresponding carriage rate of nontypable H. influenzae was 5.8% (95% CI 1.4 to 7.6%) in Chinese and 65.4% (95% CI 58.9 to 69.8) in Vietnamese.
In a larger study of 1812 healthy Chinese children between 6 months and 5 years of age investigated by throat swabs, again no Hib was isolated but 141 children (7.8%) were found to be carriers of non-type b H. influenzae.
In a study of 596 healthy Chinese children and adults, 25% had the protective level of anti-Hib antibody of>0.15 mug/ml by 1 year and 90% had reached>0.15 mug/ml by 6 years of age.
There was some evidence that these « natural » antibodies against Hib in Hong Kong Chinese were cross-reacting antibodies against antigens on other encapsulated bacteria.
Mots-clés Pascal : Bactériose, Infection, Haemophilus influenzae, Pasteurellaceae, Bactérie, Localisation, Méningite, Pneumonie, Epidémiologie, Hong Kong, Chine, Asie, Vietnamien, Réfugié, Variation saisonnière, Age, Incidence, Porteur, Nasopharynx, Immunité humorale, Anticorps naturel, Homme, Système nerveux pathologie, Système nerveux central pathologie, Haemophilus influenzae type b
Mots-clés Pascal anglais : Bacteriosis, Infection, Haemophilus influenzae, Pasteurellaceae, Bacteria, Localization, Meningitis, Pneumonia, Epidemiology, Hong Kong, China, Asia, Vietnamese, Refugee, Seasonal variation, Age, Incidence, Carrier, Nasopharynx, Humoral immunity, Natural antibody, Human, Nervous system diseases, Central nervous system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0031813
Code Inist : 002B05B02I. Création : 31/05/1999.