Nasal patency and biomarkers in nasal lavage : the significance of air exchange rate and type of ventilation in schools.
The aim of the present study was to examine the relationships between the ventilation rate and the type of ventilation system, on the one hand, and objective nasal measures, on the other.
A standardized investigation, including acoustic rhinometry and nasal lavage, was performed in the school environment.
All 279 school personnel working in the main buildings of 12 randomly selected primary schools in the municipality of Uppsala were invited, and 234 (84%) participated.
The dimensions of the nasal cavity were measured with acoustic rhinometry.
Eosinophil cationic protein (ECP), myeloperoxidase (MPO), lysozyme, and albumin were analyzed in the lavage fluid.
The air exchange rate and the room temperature were measured in the classrooms.
Relationships between nasal symptoms, nasal patency, and the concentration of biomarkers, on the one hand, and the type of ventilation system, the air exchange rate, and the temperature, on the other, were analyzed by both crude bivariate analysis and multiple regression models, controlling for the type of ventilation, the air exchange rate, room temperature, age, gender, smoking, atopy, and the urban vicinity of the school.
A lower degree of nasal patency as measured by acoustic rhinometry and increased levels of ECP and lysozyme in nasal lavage were associated with a lower air exchange rate in the schools. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Ecole primaire, Homme, Bâtiment malsain syndrome, Obstruction, Nez, Installation ventilation, Marqueur biologique, Protéine cationique éosinophile, Lysozyme, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Fosse nasale, Inflammation, Analyse statistique, Suède, Europe, ORL pathologie, Nez pathologie, Qualité air, Pollution intérieur
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Primary school, Human, Sick building syndrome, Obstruction, Nose, Ventilating equipment, Biological marker, Eosinophil cationic protein, Lysozyme, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Nasal fossa, Inflammation, Statistical analysis, Sweden, Europe, ENT disease, Nose disease, Air quality, Indoor pollution
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0031678
Code Inist : 002B10B02. Création : 31/05/1999.