We followed a group of 85 Finnish asbestosis patients radiographically for an average of 6.5 (range 2 10) years to examine the progression of the disease and to assess possible explanations for the progression.
The examinations included full-size chest radiographs and a blood specimen analysis.
The radiographs were classified according to the 1980 International Labor Office (ILO) classification.
Progression was accepted if the second or third radiography was estimated (in a side-by-side comparison) to have more profusion of small opacities qualitatively than the first. even if the radiographs were classified into the same profusion category.
In all, 38% of the patients showed progression during the follow-up period.
The average progression of small opacities ranged from ILO 1/1 to ILO 2/2 (0.4 minor ILO categories/year).
The asbestosis was progressive more often among the sprayers than among the insulators and asbestos factory workers [cross-tabulation, odds ratio (OR) 5.0,95% confidence interval (95% CI) 1.2-20]. In the logistic regression model the ILO classification category at the beginning of the follow-up (OR 1.54 ; 95% CI 0.96-2.47), the fibronectin (OR 1.01 ; 95% CI 1.00-1.01) and angiotensin-converting enzyme (ACE ; OR 1.10 ; 95% CI 1.00-1.20) levels, and the erythrocyte sedimentation rate (ESR ; OR 1.05 ; 95% CI 1.00-1.10) were statistically associated with the radiographic progression of small opacities. (...)
Mots-clés Pascal : Amiante, Valeur prédictive, Opacité, Exposition professionnelle, Médecine travail, Etude longitudinale, Homme, Asbestose, Toxicité, Evolution, Radiographie, Comparaison interindividuelle, Profession, Industrie, Surveillance biologique, Marqueur biologique, Fibronectine, Sédimentation, Erythrocyte, Appareil respiratoire pathologie, Pneumoconiose, Maladie professionnelle, Poumon pathologie, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Peptidases, Hydrolases, Enzyme
Mots-clés Pascal anglais : Asbestos, Predictive value, Opacity, Occupational exposure, Occupational medicine, Follow up study, Human, Asbestosis, Toxicity, Evolution, Radiography, Interindividual comparison, Profession, Industry, Biological monitoring, Biological marker, Fibronectin, Sedimentation, Red blood cell, Respiratory disease, Pneumoconiosis, Occupational disease, Lung disease, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Peptidases, Hydrolases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0031677
Code Inist : 002B03L03. Création : 31/05/1999.