Metabolic interferences in subjects occupationally exposed to binary styrene-acetone mixtures.
To investigate the excretion of styrene metabolites (mandelic acid, MA, and phenylglyoxylic acid, PGA) in workers employed in plastic manufacturing to verify the possible influence of coexposure to acetone on styrene metabolism.
This study was carried out on 50 workers employed in 3 factories producing polyester buttons.
The workers were divided into three groups according to three different levels of acetone exposure.
The trend of excretion for metabolites was examined during and after work shifts.
Styrene and acetone were monitored on Thursday during the entire work shift by passive dosimeters placed on the lapel of the workers'uniforms, desorbed by carbon disulfide, and analyzed by gas chromatography.
Biological monitoring was performed by determination of the urinary metabolites of styrene in urine samples collected on Thursday at the middle and the end of the work shift.
MA and PGA were determined by a highpressure liquid chromatographic method.
The styrene concentrations ranged between 16 and 439 mg/m3, and in ten samples they exceeded the TLV-TWA (213 mg/m3).
The acetone concentration ranged between 15 and 700 mg/m3 (TLV-TWA 1780 mg/m3). with the mean value being 208 mg/m3.
During cleaning operations higher exposures to acetone demonstrated, with concentrations ranging between 500 and 3400 mg/m3. (...)
Mots-clés Pascal : Styrène, Acétone, Solvant organique, Industrie chimique, Association toxique, Exposition professionnelle, Médecine travail, Métabolisme, Surveillance biologique, Marqueur biologique, Liquide biologique, Urine, Pollution air, Lieu travail, Homme, Mélange binaire, Benzène glyoxylique acide, Mandélique acide
Mots-clés Pascal anglais : Styrene, Acetone, Organic solvent, Chemical industry, Toxic association, Occupational exposure, Occupational medicine, Metabolism, Biological monitoring, Biological marker, Biological fluid, Urine, Air pollution, Work place, Human, Binary mixture
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0031676
Code Inist : 002B03L04. Création : 31/05/1999.