The introduction of routine Haemophilus influenzae type b conjugate vaccine in Chile : a framework for evaluating new vaccines in newly industrializing countries.
International Conference on Haemophilus influenzae type b infection in Asia. Bali, IDN, 1996/12/17.
To determine the burden of Haemophilus influenzae type b (Hib) disease, the safety and immunogenicity of Hib conjugate vaccine, the practicality of combining Hib conjugate and diphtheria-tetanuspertussis vaccines and the effectiveness of routine vaccination.
A series of studies were carried out involving infants and children in Santiago, Chile.
The study designs included retrospective surveillance, cost-benefit analysis, randomized placebo-controlled trials of safety and immunogenicity and a Phase IV postlicensure evaluation of vaccine effectiveness.
The studies included in this stepwise process showed that Hib invasive disease was a significant public health problem with a substantial economic burden ; that combining Hib conjugate and diphtheriatetanus-pertussis vaccines was practical, safe and elicited a strong immunologic response ; and that the combined formulation afforded a high level of protection against invasive Hib disease (90% effectiveness).
In July, 1996, Chile became only the third newly industrializing country to introduce routine Hib conjugate vaccination.
New vaccines, such as Hib conjugates, will be more expensive than existing ones.
The stepwise process used in Chile may serve as an example for the evaluation of new vaccines in nonindustrialized countries.
Mots-clés Pascal : Bactériose, Infection, Haemophilus influenzae, Pasteurellaceae, Bactérie, Prévention, Immunoprophylaxie, Implémentation, Association, Complication, Efficacité, Immunogénicité, Epidémiologie, Chili, Amérique du Sud, Amérique, Analyse coût efficacité, Surveillance, Coqueluche, Nourrisson, Homme
Mots-clés Pascal anglais : Bacteriosis, Infection, Haemophilus influenzae, Pasteurellaceae, Bacteria, Prevention, Immunoprophylaxis, Implementation, Association, Complication, Efficiency, Immunogenicity, Epidemiology, Chile, South America, America, Cost efficiency analysis, Surveillance, Whooping cough, Infant, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0031623
Code Inist : 002B05A02. Création : 31/05/1999.