Asian studies have reported that risk of nasopharyngeal cancer (NPC) is increased in individuals who frequently consume salted fish, which contains high levels of N-nitroso compounds.
As part of a collaborative, population-based, case-control study in the U.S., where the annual incidence of the disease is low, we investigated whether dietary intake of preformed nitrosamines or nitrosamine precursors, or of antioxidants including vitamin C and carotenoids, was associated with altered risk of NPC overall, or of specific histologic subtypes of disease.
Cases (n=133) identified at 5 population-based cancer registries and controls (n=212) identified through random digit dialing completed a telephone interview and self-administered food frequency questionnaire.
Dietary exposures were expressed as quartiles of intake, and odds ratios (ORs) calculated using the lowest quartile of intake as the reference category.
Risk of non-keratinizing and undifferentiated tumors of the nasopharynx was increased in frequent consumers of preserved meats, which contain high levels of added nitrites.
ORs in the 2nd, 3rd and highest quartile were 1.99,4.35 and 4.59, although 95% confidence intervals did not exclude 1.0. Risk of differentiated squamous cell carcinoma, but not other histologic types, was significantly reduced in individuals with vitamin C intake above the lowest quartile (ORs 0.30,0.33 and 0.30 in the 2nd, 3rd and highest quartiles, respectively). (...)
Mots-clés Pascal : Tumeur maligne, Nasopharynx, Facteur risque, Epidémiologie, Alimentation, Nitrosamine, Précurseur, Nitrite, Antioxydant, Acide ascorbique, Vitamine, Caroténoïde, Viande, Conservation, Etats Unis, Amérique du Nord, Amérique, Etude cas témoin, Homme, ORL pathologie, Pharynx pathologie
Mots-clés Pascal anglais : Malignant tumor, Nasopharynx, Risk factor, Epidemiology, Feeding, Nitrosamine, Precursor, Nitrites, Antioxidant, Ascorbic acid, Vitamin, Carotenoid, Meat, Conservation, United States, North America, America, Case control study, Human, ENT disease, Pharynx disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0027468
Code Inist : 002B10B01. Création : 31/05/1999.