This study aimed to assess the main features of hepatocellular carcinoma at the time of diagnosis in Italy, particularly in relation to the presence or absence of underlying cirrhosis, hepatitis virus marker patterns, age of the subjects and alpha-foetoprotein values Methods : A total of 1148 patients with hepatocellular carcinoma seen at 14 Italian hospitals in the 1-year period from May 1996 to May 1997 were the subjects of this prevalence study.
Both newly diagnosed cases (incident cases) and cases diagnosed before May 1996 but still attending the hospitals during the study period (prevalent cases) were included.
We found that 71.1% of cases were positive for hepatitis C virus antibodies but negative for HBsAg ; in contrast, 11.5% were negative for anti-HCV but positive for HBsAg ; 5.3% were positive for both markers ; and 12.1% were negative for both viruses.
The mean age of detection was over 60 years, with a younger mean age in HBsAg-positive compared to anti-HCV-positive patients (59.3 years vs. 65.6 years, p<0.01).
The male-to-female ratio among HBsAg-positive patients was 10.4 : 1, in contrast to 2.8 : 1 among anti-HCV-positive patients (p<0.01).
The majority of cases (93.1%) had underlying cirrhosis.
Cirrhotic patients were more likely to be anti-HCV positive than non-cirrhotic cases (73.2% vs 43.9%) (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Incidence, Facteur risque, Hépatite virale, Virose, Infection, Cirrhose, Association morbide, Age, Marqueur tumoral, Epidémiologie, Homme, Italie, Europe, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Hepatocellular carcinoma, Incidence, Risk factor, Viral hepatitis, Viral disease, Infection, Cirrhosis, Concomitant disease, Age, Tumoral marker, Epidemiology, Human, Italy, Europe, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0027436
Code Inist : 002B30A01A2. Création : 31/05/1999.