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  1. Fulltext. Bovine spongiform encephalopathy and new variant Creutzfeldt-Jakob disease.

    Article - En anglais

    Fulltext.

    Bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob Disease (CJD) belong to a group of degenerative neurological disorders collectively known as the transmissible spongiform encephalopathies (TSEs).

    The group also includes scrapie of sheep and goats, kuru of humans, chronic wasting disease of mule deer and elk and transmissible encephalopathy of mink.

    These fatal diseases cause behavioural changes, alterations of sensation, changes in mental state and ataxia.

    The typical pathology is non-inflammatory vacuolation (spongiosis) in neuronal perikarya and in the grey matter neuropil.

    Occasionally, there may also be amyloid plaque deposition in certain regions of the brain and, less frequently, the spinal cord.

    All the diseases have long incubation periods which, depending on the host, may range from many months to several decades.

    Death is inevitable after a slow progressive illness.

    In this review, I shall cover the recent UK outbreak of BSE and its relationship to new variant Creutzfeldt-Jakob disease.

    Mots-clés Pascal : Encéphalopathie spongiforme, Etiopathogénie, Exploration clinique, Encéphalopathie spongiforme Creutzfeldt Jakob, Infection, Variante, Caractéristiques, Facteur risque, Transmission animal homme, Homme, Prion, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative

    Mots-clés Pascal anglais : Spongiform encephalopathy, Etiopathogenesis, Clinical investigation, Creutzfeldt Jakob disease, Infection, Process variant, Characteristics, Risk factor, Transmission from animal to man, Human, Prion, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0027041

    Code Inist : 002B17G. Création : 31/05/1999.