Estrogens have been implicated in the development of breast cancer.
Preliminary evidence suggests that consumption of soy products, which contain isoflavones (phytoestro-gens), can reduce serum estrogen levels.
Our purpose was to determine the effect of soy consumption on serum estrogen levels in premenopausal women by use of a dietary intervention approach.
Premenopausal Japanese women were randomly assigned to receive either a soymilk-supplemented diet (n=31) or a normal (control) diet (n=29).
The women in the soymilk-supplemented group were asked to consume about 400 mL of soymilk (containing about 109 mg of isoflavones) daily during a study period that involved three consecutive menstrual cycles.
Follicular-phase blood samples were to be obtained in the menstrual cycles preceding (cycle 1) and following (cycle 3) the 2-month dietary intervention.
All statistical tests were two-sided.
At the end of the study period, estrone and estradiol levels were decreased by 23% and 27%, respectively, in the soymilk-supplemented group and were increased by 0.6% and 4%, respectively, in the control group.
The changes for each hormone between the two groups were not statistically significantly different.
In the soymilk-supplemented group, menstrual cycle length was increased by nearly 2 days, and, in the control group, it was decreased by approximately 1 day, a difference that was not statistically significant. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Consommation alimentaire, Oestrogène, Lait soja, Préménopause, Japon, Asie, Prévention, Isoflavone dérivé, Origine végétale, Alimentation, Homme, Glande mammaire pathologie, Hormone stéroïde sexuelle, Hormone ovarienne
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Food intake, Estrogen, Soybean milk, Premenopause, Japan, Asia, Prevention, Isoflavone derivatives, Plant origin, Feeding, Human, Mammary gland diseases, Sex steroid hormone, Ovarian hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0026755
Code Inist : 002B20E02. Création : 31/05/1999.