Our aim was to study the incidence of Helicobacter pylori recurrence in our country and to assess the different variables that might influence it.
We studied prospectively 331 duodenal ulcer patients (mean age, 48 ± 14 years, 71% male) in whom H. pylori had been eradicated.
Several therapies were used, classified as low-efficacy (omeprazole+amoxycillin, 32% eradication rate ; omeprazole+amoxycillin+metronidazole, 56%) and high-efficacy therapies (omeprazole+clarithromycin+amoxycillin or metronidazole, 88% ; bismuth triple therapy. 77%). One month after completion of therapy an endoscopy with biopsies and/or 13C-urea breath test was performed.
A breath test was carried out again at 6 months, I year, and 2 years, to study H. pylori recurrences.
Endoscopy (with biopsies) was performed only to confirm recurrences.
Multiple logistic regression analysis was used.
Differences between Kaplan-Meier curves were evaluated with the log-rank test.
Sixty-seven patients were followed up for 6 months, 136 for t year, and 128 for 2 years, giving 425 patient-years of follow-up.
A total of 18 H. pylori recurrences was observed (12 at 6 months, 4 at 1 year, and 2 after 2 years), yielding a yearly recurrence of 4.2% patient-years-1.
The respective risk of H. pylori recurrence for each period was 3.6% (95% confidence interval (Cl). 2.1% - 6.2%), 1.5% (0.6% - 3.8%), and 1.5% (0.4% - 5.5%). The probability of being H. (...)
Mots-clés Pascal : Ulcère, Duodénum, Récurrence, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Incidence, Eradication, Réinfection, Etude longitudinale, Homme, Espagne, Europe, Appareil digestif pathologie, Intestin pathologie, Bactériose, Infection, Recrudescence
Mots-clés Pascal anglais : Ulcer, Duodenum, Recurrence, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Incidence, Eradication, Reinfection, Follow up study, Human, Spain, Europe, Digestive diseases, Intestinal disease, Bacteriosis, Infection
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0026713
Code Inist : 002B05B02F. Création : 31/05/1999.