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  1. Diabetic microangiopathy.

    Article, Communication - En anglais

    International Novo Nordisk Symposium on Diabetes in Chilhood and Adolescence. Copenhagen, DNK, 1997/11/07.

    Microvascular complications of diabetes include retinopathy, nephropathy and neuropathy.

    The first signs of these complications may develop in children and adolescents, particularly if insulin treatment has been inadequate.

    The mechanisms by which diabetic microengiopathy develop are not know, but probably include genetic influences.

    Several biochemical changes are increased protein glycation.

    Important functional changes are increased organ blood flow, increased vascular permeability, abnormal blood viscosity and abnormal platelet and endothelial function.

    The structural hallmark of diabetic microangiopathy is the thickening of the capillary basement membrane.

    These changes may lead to occlusive angiopathy and to tissue hypoxia and damage.

    Screening for microangiopathy should start in children and adolescents after 5-y duration of the disease and 10 y of age.

    The screening should include retinal examination through a dilated pupil or fundus photography, urinary albumin excretion rate, blood pressure measurement and neurological examination.

    Several intervention trials have shown that near normoglycaemia may reduce the risk of microangiopathy.

    There is a curvilinear association between the risk of development and progression of microangiopathy and mean blood glucose.

    Therefore, optimal insulin treatment is important in children and adolescents.

    Mots-clés Pascal : Diabète insulinodépendant, Complication, Microangiopathie, Dépistage, Etiopathogénie, Prédisposition, Génétique, Biologie clinique, Histopathologie, Epidémiologie, Prévention, Contrôle, Glycémie, Adaptation posologie, Enfant, Homme, Adolescent, Endocrinopathie, Immunopathologie, Maladie autoimmune, Vaisseau sanguin pathologie, Appareil circulatoire pathologie, Anatomopathologie

    Mots-clés Pascal anglais : Insulin dependent diabetes, Complication, Microangiopathy, Medical screening, Etiopathogenesis, Predisposition, Genetics, Clinical biology, Histopathology, Epidemiology, Prevention, Check, Glycemia, Dosage adjustment, Child, Human, Adolescent, Endocrinopathy, Immunopathology, Autoimmune disease, Vascular disease, Cardiovascular disease, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0026078

    Code Inist : 002B21E01B. Création : 31/05/1999.