Low insulin, IGF-I and IGFBP-3 levels in children with Prader-Labhart-Willi syndrome.
It is well established that insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and insulin are low in growth hormone deficiency, but due to their dependence on nutrition, they are elevated in healthy obese children.
As the presence of growth hormone deficiency in Prader-Labhart-Willi syndrome (PWS) is still controversial, we studied insulin, IGF-I and IGFBP-3 levels in 19 children with PWS (age range 0.5-14.6 years).
Serum concentrations of insulin (SDS : - 0.7 ± 0.9, P=0.01) and IGF-I (SDS : - 0.7 ± 0.8, P=0.002) were low, but IGFBP-3 (SDS : - 0.3 ± 1.2, P=0.2) was normal compared to normal weight age-matched children.
Since children with PWS are typically obese, insulin, IGF-I and IGFBP-3 levels should be compared to normal obese children who present increased levels of these hormones.
In comparison to data of healthy obese children reported in the literature, not only IGF-I, but also IGFBP-3 levels are low and fasting insulin levels even very low, suggesting a growth hormone deficiency.
Mots-clés Pascal : Prader Labhart Willi syndrome, Déficit, STH, Association, Etude statistique, Etude comparative, Obésité, Suisse, Europe, Anthropométrie, Insuline, Facteur croissance IGF1, Protéine liaison IGFBP, Enfant, Homme, Adolescent, Endocrinopathie, Système ostéoarticulaire pathologie, Maladie héréditaire, Syndrome complexe, Biologie clinique
Mots-clés Pascal anglais : Prader Labhart Willi syndrome, Deficiency, Somatotropin hormone, Association, Statistical study, Comparative study, Obesity, Switzerland, Europe, Anthropometry, Insulin, Insulin like growth factor 1, Insulin like growth factor binding protein, Child, Human, Adolescent, Endocrinopathy, Diseases of the osteoarticular system, Genetic disease, Complex syndrome, Clinical biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0026043
Code Inist : 002B21A01. Création : 31/05/1999.