Vitamin D receptor alleles predict growth and bone density in girls.
Objectives-Polymorphism of the vitamin D receptor (VDR), collagen alpha I type I (Col I alphaI), and oestrogen receptor (ER) genes have been shown to account for some of the heritability of bone mineral density (BMD) in adults.
This study examined this relation in prepubertal children.
Methods and subjects-The relation between genotypes of VDR gene (Taq I, Bsm I, Fok I), Col I alphaI gene (Msc I), and ER gene (Pvu II) with areal BMD, volumetric BMD, and growth were examined in 114 (68 girls) healthy 7 year old, white children.
The genotype of the VDR gene (Taq I) correlated with lumbar spine (L1-4) volumetric BMD in girls only, but at no other bone sites.
In girls, VDR genotype affected areal BMD at all sites.
After adjusting for height and weight, however, this effect was explained completely by the independent effect of the VDR genotype on growth.
Girls with genotype TT, were 3.9 kg heavier and 4. cm taller than those with tt, but this relation was not present at birth.
No relation was found between genotypes of the VDR gene (Fok I), Col I alphaI gene (Msc I), or ER gene (Pvu II) and BMD or growth variables.
Conclusions-In prepubertal girls, VDR alleles contribute to lumbar spine volumetric BMD variance, but the areal BMD effect reflects the relation between areal BMD and growth.
VDR alleles might affect postnatal growth regulation.
Mots-clés Pascal : Polymorphisme, Allèle, Récepteur, Vitamine D, Corrélation, Développement staturopondéral, Masse osseuse, Femelle, Rachis lombaire, Etude statistique, Etude comparative, Australie, Océanie, Réaction chaîne polymérase, Enfant, Homme, Prépuberté, Déterminisme génétique, Biologie moléculaire
Mots-clés Pascal anglais : Polymorphism, Allele, Receiver, Vitamin D, Correlation, Somatic growth, Bone mass, Female, Lumbar spine, Statistical study, Comparative study, Australia, Oceania, Polymerase chain reaction, Child, Human, Prepuberty, Genetic determinism, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0025776
Code Inist : 002B15I. Création : 31/05/1999.