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  1. Risk factors for breakthrough varicella in healthy children.

    Article - En anglais

    Aim-To evaluate the risk factors for breakthrough varicella in a follow up study of a cohort of 181 healthy children immunised when aged 9-24 months with a reformulated Oka strain varicella vaccine (SmithKline Beecham Biologicals/Oka).

    Design-The children were randomised in a double blind manner into one of four groups to receive one of two production lot vaccine batches, at two different titres (high titre, 103.9 and 104.0 plaque forming units (pfu) ; low titre (heat exposed), 102.7 and 102.8 pfu).

    The overall seroconversion rate after immunisation was 99%. Results-One hundred and sixty eight patients were available for review after a mean (SD) follow up of 35 (9) months after vaccination.

    Multivariate analysis indicated that risk factors for breakthrough varicella were household contact with varicella (adjusted odds ratio (OR), 19.89 ; 95% confidence interval (CI), 18.39 to 21.39), vaccination age of <= 14 months (adjusted OR, 2.30 ; 95% CI, 1.69 to 2.90), and receiving low titre (102 pfu) vaccine (adjusted OR, 2.13 ; 95% CI, 1.54 to 2.73).

    All children who developed breakthrough varicella, had a modified varicella illness, except for three, all of whom had received low titre vaccine.

    Conclusion-The identification of young immunisation age (<= 14 months) and low titre vaccine as risk factors for breakthrough varicella have important implications for the implementation of varicella vaccination programmes in healthy children.

    Mots-clés Pascal : Varicelle, Virose, Infection, Vaccination, Immunisation, Long terme, Etude cohorte, Etude statistique, Etude double insu, Facteur risque, Age, Titre, Vaccin, Singapour, Asie, Nourrisson, Homme, Enfant, Virologie, Epidémiologie

    Mots-clés Pascal anglais : Varicella, Viral disease, Infection, Vaccination, Immunization, Long term, Cohort study, Statistical study, Double blind study, Risk factor, Age, Title, Vaccine, Singapore, Asia, Infant, Human, Child, Virology, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0025775

    Code Inist : 002B05A02. Création : 31/05/1999.