Dextropropoxyphene (DXP) is one of the most prescribed analgesic compounds in Sweden.
To investigate the manner of death among fatalities where DXP caused or contributed to death all medico-legal autopsies performed in Sweden in 1992-1996 were analysed on the bases of toxicological analyses and death certificates.
DXP in peripheral blood was found in 1782 (7.5%) of the total 23 691 blood samples.
According to the death certificates 956 (54%) of the 1782 cases were classified as fatal DXP poisoning.
Among these, the manner of death was classified as accidental in 49 cases (5%), suicidal in 542 cases (57%) and undetermined in 365 cases (38%). The reported manner of death differed between the six forensic medicine districts in Sweden.
The accident rate differed significantly between the district with the highest rate (9%) and the districts with the lowest rate (1%). One district had a significantly higher incidence of suicide (73%) than four of the other districts, while another district had a significantly lower incidence of suicide (33%) than all the other districts.
The accident classification rate among the physicians performing ten or more autopsies varied from 0% to 17%, the suicide classification rate from 25% to 83% and the rate of undetermined manner of death from 8% to 71%. A major conclusion drawn from this study is that accidental DXP fatalities may be underestimated. (...)
Mots-clés Pascal : Dextropropoxyphène, Analgésique, Intoxication médicamenteuse, Abus, Suicide, Toxicité, Statistique, Epidémiologie, Suède, Europe, Homme, Typologie, Mort, Médecine légale
Mots-clés Pascal anglais : Dextropropoxyphene, Analgesic, Drug intoxication, Abuse, Suicide, Toxicity, Statistics, Epidemiology, Sweden, Europe, Human, Typology, Death, Legal medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0025746
Code Inist : 002B02V. Création : 31/05/1999.