Indeterminate pattern of results in Western blot (WBI) for human immunodeficiency virus type-1 (HIV-1) infection may represent early HIV-1 infection or may be non-specific in origin.
This issue can be resolved by follow up testing upto at least 6 months resulting in psychological distress as well as in high drop out rates among those undergoing investigation pointing out the need for additional parameters that could help in determining the status of HIV-1 infection at the time of initial testing itself in individuals with WBI pattern.
The objectives of the present study were :
(i) to determine the frequency of HIV-I infected individuals in a group of professional donors showing WBI patterns in initial testing on the basis of follow up serological studies ;
(ii) to find out if any HIV related epidemiological or serological characteristics recorded at the time of initial testing could be considered as predictor for HIV-1 infection in WBI specimens ;
and (iii) to evaluate two alternative serodiagnostic strategies for HIV-1 infection viz. multiple EIAs based on different antigen preparations/principles and a line immunoassay (LIA) employing recombinant antigens in resolving status of HIV-1 infection in specimens showing WBI results at initial testing. (...)
Mots-clés Pascal : Virus HIV1, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Analyse risque, Risque infectieux, Contamination biologique, Facteur prédictif, Sérologie, Donneur sang, SIDA, Virose, Infection, Epidémiologie, Immunopathologie, Immunodéficit, Homme
Mots-clés Pascal anglais : HIV-1 virus, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Risk analysis, Infectious risk, Biological contamination, Predictive factor, Serology, Blood donor, AIDS, Viral disease, Infection, Epidemiology, Immunopathology, Immune deficiency, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0025661
Code Inist : 002B05C02D. Création : 31/05/1999.