Effect of BRCA1 and BRCA2 on the association between breast Cancer risk and family history.
The discovery of BRCA1 and BRCA2 has led to a reassessment of the association between family history of breast/ovarian cancer and breast cancer risk after controlling for carrier status for mutations in the BRCA1 and BRCA2 genes.
We examined whether family history of breast cancer remains a predictive risk factor for this disease after carrier status for BRCA1 and/or BRCA2 mutations is taken into consideration.
The data are from 4730 case subjects with breast cancer and 4688 control subjects enrolled in the Cancer and Steroid Hormone Study.
The probability of being a BRCA1 and/or BRCA2 gene carrier was calculated for each woman.
Among predicted noncarriers, logistic regression was used to assess the relationship (odds ratios and 95% confidence intervals [CIs]) between case or control status and family history of breast or ovarian cancer.
Estimates of age-specific breast cancer risk are presented by predicted carrier status.
Among predicted noncarriers, case subjects were 2.06 times (95% CI=1.69-2.50) and 1.24 times (95% CI=1.17-1.32) more likely to report a first-degree or second-degree family history of breast cancer, respectively, than were control subjects.
Case subjects were 1.99 times (95% CI=1.63-2.44), 1.66 times (95% CI=1.18-2.38), and 2.23 times (95% CI=0.21-24.65) more likely to report an affected mother, sister, or both, respectively, than were control subjects. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Antécédent, Histoire familiale, Gène suppresseur tumeur, Mutation, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Glande mammaire pathologie, Génétique, Gène BRCA1, Gène BRCA2
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Antecedent, Family story, Tumor suppressor gene, Mutation, Epidemiology, United States, North America, America, Human, Mammary gland diseases, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0024653
Code Inist : 002B20E02. Création : 31/05/1999.