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  1. Occurrence of hemophilia in the United States.

    Article - En anglais

    An active surveillance system was used to identify all residents with hemophilia in six U.S. states (Colorado, Georgia, Louisiana, Massachusetts, New York, and Oklahoma).

    A hemophilia case was defined as a person with physician-diagnosed hemophilia A or B andlor a measured baseline factor VIII or IX activity (FA) of 30% or less.

    Case-finding methods included patient reports from physicians, clinical laboratories, hospitals, and hemophilia treatment centers.

    Once identified, trained data abstractors collected clinical and outcome data retrospectively from medical records.

    Among cases identified in 1993-1995,2,743 were residents of the six states in 1994, of whom 2,156 (79%) had hemophilia A. Of those with available FA measurements, 1,140 (43%) had severe (FA<1%), 684 (26%) had moderate (FA 1% - 5%), and 848 (31%) had mild (FA 6% - 30%) disease.

    The mean and median age was 25.4 and 23 years, respectively.

    The age-adjusted prevalence of hemophilia in all six states in 1994 was 13.4 cases/100,000 males (10.5 for hemophilia A and 2.9 for B).

    The prevalence by race/ethnicity was 13.2 cases/100,000 among white, 11.0 among African American, and 11.5 among Hispanic males.

    Application of age-specific prevalence rates from the six surveillance states to the U.S. population resulted in an estimated national population of 13,320 cases of hemophilia A and 3,640 cases of hemophilia B. (...)

    Mots-clés Pascal : Hémophilie, Prévalence, Incidence, Surveillance sanitaire, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Hémopathie, Coagulopathie, Maladie héréditaire

    Mots-clés Pascal anglais : Hemophilia, Prevalence, Incidence, Sanitary surveillance, Epidemiology, United States, North America, America, Human, Hemopathy, Coagulopathy, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0024551

    Code Inist : 002B19C. Création : 31/05/1999.