Relationship between number of ovulatory cycles and accumulation of mutant p53 in epithelial ovarian cancer.
It has been suggested that increased numbers of ovulations might increase the risk of p53 gene (also known as TP53) mutation in the ovarian epithelium, thereby leading to the development of cancer.
The data supporting this hypothesis have come from an observation that accumulation of p53 protein in epithelial ovarian cancel was strongly associated with increasing numbers of ovulatory cycles.
We have further investigated the association between ovulatory history and p53 gene mutation by use of data from a large case-control study of ovarian cancer in Australia.
Tissue blocks were available for immunohistochemical analysis of p53 protein from 234 case subjects, aged 18-79 years, who had invasive epithelial ovarian cancer.
Epidemiologic data were also available for these women and for 855 control subjects.
Case-case comparisons were made by use of prevalence ratios and 95% confidence intervals (CIs), and case-control comparisons were made by use of odds ratios (ORs) and 95% CIs.
All statistical tests were two-sided.
There was no association between p53 accumulation and years of ovulation.
Women with p53-positive cancers had undergone an average of 29.3 years of ovulation compared with 29.0 years of ovulation for women with p53-negative cancers (P=8).
Although the overall risk of ovarian cancer development was significantly increased in women who had undergone more years of ovulation (OR=2.17 ; 95% CI=1.54-3. (...)
Mots-clés Pascal : Tumeur maligne, Ovaire, Facteur risque, Epidémiologie, Gène suppresseur tumeur, Gène TP53, Cycle ovulatoire, Nombre, Australie, Océanie, Etude cas témoin, Homme, Appareil génital femelle pathologie, Ovaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Ovary, Risk factor, Epidemiology, Tumor suppressor gene, TP53 Gene, Ovulatory cycle, Number, Australia, Oceania, Case control study, Human, Female genital diseases, Ovarian diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0023598
Code Inist : 002B20C02. Création : 31/05/1999.