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  1. Occupational asthma by Anisakis simplex.

    Article - En anglais

    Background 

    No cases of occupational asthma caused by the inhalation of antigens from Anisakis simplex have been published.

    Objective 

    The purpose of this study was to evaluate the possibility that A simplex can play a role in the asthma experienced by 2 workers when handling fish and fish flour.

    Methods 

    Skin prick and bronchial challenge tests with A simplex were performed.

    We also carried out measurements of specific IgE to A simplex and immunoblotting.

    Results 

    Both patients had strong positive skin test responses, challenge test responses, and specific IgE to A simplex.

    Immunoblotting showed that both patients also had IgE against several bands in the fish flour extract, suggesting contamination by Anisakis allergens.

    Conclusion 

    These 2 patients provide evidence for occupational asthma caused by A simplex, based on in vivo and in vitro tests for Anisakis-specific IgE.

    Mots-clés Pascal : Asthme, Allergie, Anisakis simplex, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Exposition professionnelle, Pisces, Vertebrata, Allergène, Etude cas, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Médecine travail

    Mots-clés Pascal anglais : Asthma, Allergy, Anisakis simplex, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Occupational exposure, Pisces, Vertebrata, Allergen, Case study, Human, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0023154

    Code Inist : 002B06C02. Création : 31/05/1999.