No cases of occupational asthma caused by the inhalation of antigens from Anisakis simplex have been published.
The purpose of this study was to evaluate the possibility that A simplex can play a role in the asthma experienced by 2 workers when handling fish and fish flour.
Skin prick and bronchial challenge tests with A simplex were performed.
We also carried out measurements of specific IgE to A simplex and immunoblotting.
Both patients had strong positive skin test responses, challenge test responses, and specific IgE to A simplex.
Immunoblotting showed that both patients also had IgE against several bands in the fish flour extract, suggesting contamination by Anisakis allergens.
These 2 patients provide evidence for occupational asthma caused by A simplex, based on in vivo and in vitro tests for Anisakis-specific IgE.
Mots-clés Pascal : Asthme, Allergie, Anisakis simplex, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Exposition professionnelle, Pisces, Vertebrata, Allergène, Etude cas, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Médecine travail
Mots-clés Pascal anglais : Asthma, Allergy, Anisakis simplex, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Occupational exposure, Pisces, Vertebrata, Allergen, Case study, Human, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0023154
Code Inist : 002B06C02. Création : 31/05/1999.