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  1. Does treated primary hypertension lead to end-stage renal disease ? A 20-year follow-up of the primary prevention study in Göteborg, Sweden.

    Article - En anglais


    Hypertension is reported to be one of the most common causes of end-stage renal disease (ESRD) in Europe and in the United States.

    However, the frequency with which treated primary hypertension leads to renal failure is not known.

    The majority of patients with ESRD have hypertension.

    Whether this is the cause or the consequence of the impaired renal function is often not possible to establish.


    To determine if treated primary hypertension can lead to ESRD, we studied the development of serum creatinine levels in 686 white hypertensive men, recruited from a random third of the male population aged 47-55 years living in Göteborg, Sweden (n=9998 ; 7495 participants).

    At entry and during 20 years follow-up, all signs of kidney disease, secondary hypertension, or increase in blood pressure were investigated.

    Records of patients with a serum creatinine value <=130 mumol/l at any time during the observation period were thoroughly studied to ascertain the cause of the impaired renal function.


    A serum creatinine level above 130 mumol was seen in 8.9% (61/686) of the treated hypertensives during the 20 years of follow-up.

    An underlying renal disorder was found in 7.2% (49/686) of the patients ; renoparenchymal disease (2.2%), renovascular disease (1.5%), diabetic nephropathy (1.2%) or a urological disease (1.6%). Only 1.7% (12/686) of the hypertensives showed a moderate progressive increase in serum creatinine of unknown cause. (...)

    Mots-clés Pascal : Hypertension artérielle, Primitif, Effet biologique, Chimiothérapie, Incidence, Insuffisance rénale, Stade terminal, Epidémiologie, Homme, Appareil circulatoire pathologie, Appareil urinaire pathologie, Rein pathologie

    Mots-clés Pascal anglais : Hypertension, Primitive, Biological effect, Chemotherapy, Incidence, Renal failure, Terminal stage, Epidemiology, Human, Cardiovascular disease, Urinary system disease, Kidney disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0022193

    Code Inist : 002B14A05. Création : 31/05/1999.