Additional genetic risk factors for venous thromboembolism in carriers of the factor V Leiden mutation.
Only a minority of subjects with factor V (FV) Leiden mutation develop venous thromboembolism (VTE), suggesting that additional genetic risk factors may be present in symptomatic carriers.
We screened 15 7 unrelated carriers of the FV Leiden mutation with a first episode of VTE and 29 1 unrelated asymptomatic FV carriers for the presence of two frequent mutations, i.e. G20210A of the prothrombin gene and C677T of the methylenetetrahydrofolate reductase gene.
Carriers with other inherited or acquired thrombophilia-associated abnormalities were excluded from analysis.
Heterozygotes for the G20210A mutation were more prevalent among symptomatic carriers than in asymptomatic carriers (10.8% v 2.7%. P<0.0001) ; homozygotes for the C677T mutation were also more prevalent in symptomatic carriers (21.6% v 14.4%, P=0.05).
Factor V Leiden carriers who had had a VTE episode during oral contraceptive intake were more frequently carriers of the G2021 0A mutation (14.3%, P=0.03).
These results further support the idea that VTE in carriers of FV Leiden results from interaction with additional genetic or circumstantial risk factors, and that an accurate search for such factors is required to identify carriers at risk.
Mots-clés Pascal : Thrombose profonde, Veine, Facteur risque, Facteur V Leiden, Mutation, Gène, Prothrombine, Facteur coagulation, Methylenetetrahydrofolate reductase (NADPH), Oxidoreductases, Enzyme, Résistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Epidémiologie, Italie, Europe, Homme, Asymptomatique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Génétique, Hémopathie, Coagulopathie, Maladie héréditaire
Mots-clés Pascal anglais : Deep vein thrombosis, Vein, Risk factor, Factor V Leiden, Mutation, Gene, Prothrombin, Coagulation factor, Methylenetetrahydrofolate reductase (NADPH), Oxidoreductases, Enzyme, Resistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Epidemiology, Italy, Europe, Human, Asymptomatic, Cardiovascular disease, Vascular disease, Venous disease, Genetics, Hemopathy, Coagulopathy, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0020287
Code Inist : 002B12B03. Création : 31/05/1999.