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  1. Prevalence of elevated serum transferrin saturation in adults in the United States : Iron overload, public health, and genetics.

    Article - En anglais

    Background 

    A population-based hemochromatosis screening program that uses serum transferrin saturation has been proposed, but few data exist on the number of U.S. adults that such a program would identify for further testing.

    Objective 

    To determine the prevalence of an initially elevated serum transferrin saturation and the prevalence of concurrently elevated serum transferrin saturation and serum ferritin levels in the adult population of the United States.

    Design 

    Nationally representative cross-sectional survey of the noninstitutionalized U.S. civilian population.

    Participants 

    15 839 men and nonpregnant women 20 years of age and older who were examined in the third National Health and Nutrition Examination Survey (1988-1994).

    Measurements 

    Single measurements of serum transferrin saturations and serum ferritin levels.

    Cut-off values used to define elevated serum transferrin saturation ranged from greater than 45% to greater than 62%. Results : The prevalence of initially elevated serum transferrin saturation ranged from 1% to 6%. Approximately 11% to 22% of those with elevated serum transferrin saturation had concurrently elevated serum ferritin levels.

    The prevalence of elevated serum transferrin saturation was lower in women than in men when the same cut-off value was used to define elevated serum transferrin saturation. (...)

    Mots-clés Pascal : Hémochromatose, Dépistage, Saturation, Transferrine, Prévalence, Base donnée, Analyse quantitative, Population, Etats Unis, Amérique du Nord, Amérique, Homme, Fer, Métabolisme pathologie, Enzymopathie, Biologie moléculaire

    Mots-clés Pascal anglais : Hemochromatosis, Medical screening, Saturation, Transferrin, Prevalence, Database, Quantitative analysis, Population, United States, North America, America, Human, Iron, Metabolic diseases, Enzymopathy, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0019844

    Code Inist : 002B22E03. Création : 31/05/1999.