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  1. Hemochromatosis-associated Mortality in the United States from 1979 to 1992 : An analysis of Multiple-Cause Mortality data : Iron overload, public health, and genetics.

    Article - En anglais


    Hemochromatosis, which can lead to serious chronic diseases resulting from iron overload, has an estimated prevalence of 50 to 80 cases per 10 000 persons.

    However, little population-based information is available on the impact of hemochromatosis on morbidity and mortality.


    To evaluate trends over 14 years in deaths and medical conditions associated with hemochromatosis in the United States.


    We searched Multiple-Cause Mortality Files compiled by the National Center for Health Statistics for the years 1979 to 1992 for all records listing hemochromatosis.

    We used these data to calculate age-adjusted and age-specific mortality rates, identify medical conditions associated with a known diagnosis of hemochromatosis at death, and calculate proportionate mortality ratios for these medical conditions.


    The listing of hemochromatosis on death certificates increased 60% from 1979 to 1992.

    Decedents with hemochromatosis were 23,13, and 5 times more likely to have liver neoplasms, liver disease, and cardiomyopathy, respectively, than were decedents without hemochromatosis.

    Conversely, decedents with liver neoplasms, liver disease, and cardiomyopathy were 26,14, and 5 times more likely, respectively, to have hemochromatosis than were decedents without these conditions. (...)

    Mots-clés Pascal : Hémochromatose, Dépistage, Association, Mortalité, Etude comparative, Etiologie, Corrélation multiple, Certificat décès, Evaluation, Etats Unis, Amérique du Nord, Amérique, Homme, Fer, Métabolisme pathologie, Enzymopathie

    Mots-clés Pascal anglais : Hemochromatosis, Medical screening, Association, Mortality, Comparative study, Etiology, Multiple correlation, Death certificate, Evaluation, United States, North America, America, Human, Iron, Metabolic diseases, Enzymopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0018852

    Code Inist : 002B22E03. Création : 31/05/1999.