A multiethnic cohort of adult members of the Kaiser Permanente Medical Care Program (55300 men and 65271 women) was followed for 15 years (1979-93) to assess the association between total cholesterol and risk of infections (other than respiratory and HIV) diagnosed in the in-patient setting.
Using multivariate Cox regression, total cholesterol was inversely and significantly related to urinary tract, venereal, musculo-skeletal, and all infections among men ; and to urinary tract, all genito-urinary, septicaemia or bacteraemia, miscellaneous viral site unspecified, and all infections among women.
The reduction of risk of all infections associated with a 1 S.D. increase in total cholesterol was 8% in both men (95% CI, 4-12%) and women (95% CI, 5-11%). For urinary tract infections among men, as for septicaemia or bacteraemia and nervous system infections among women, the risk relation was restricted to persons aged 55-89 years.
Nervous system infections were positively related to total cholesterol among women aged 25-54.
In both genders, the significant inverse association with all infections persisted after excluding the first 5 years of follow-up.
Collectively, these data are suggestive of an inverse association, although not entirely consistent, between total cholesterol and incidence of infections either requiring hospitalization or acquired in the hospital. (...)
Mots-clés Pascal : Homme, Infection nosocomiale, Epidémiologie, Milieu hospitalier, Facteur risque, Cholestérolémie, Analyse statistique, Age, Sexe
Mots-clés Pascal anglais : Human, Nosocomial infection, Epidemiology, Hospital environment, Risk factor, Cholesterolemia, Statistical analysis, Age, Sex
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0017803
Code Inist : 002B05A02. Création : 31/05/1999.