To assess the role of cardiovascular risk factors, measured at the time of diagnosis, in the pathogenesis of giant cell (temporal) arteritis (GCA).
Four hundred new patients with GCA or polymyalgia rheumatica (PMR) and population-based, individually age-and sex-matched controls were included in this multicenter, prospective case-control study.
Each participant was evaluated by review of the medical history and by clinical and laboratory assessments.
Among women, smoking was associated with a 6-fold increase in risk (P=0.00006,95% confidence interval [95% CI] 2-17), heavy smoking with a 17-fold increase in risk, and previous atheromatous disease with a 4.5-fold increase in risk (P=0.0003,95% CI 2-11) of GCA in both the biopsy-positive and biopsy-negative GCA groups ; only smoking appeared to be a risk factor for PMR in women (odds ratio 3.64,95% CI 1.07-12.40).
Among men, no risk factor was found to be significant.
Smoking and previous arterial disease were independently associated with GCA in women.
In order to avoid matching bias, risk factors for diseases with an unbalanced sex distribution should be studied separately in each sex, using a sex-matched, case-control study design.
Mots-clés Pascal : Horton maladie, Personne âgée, Homme, Pathogénie, Pseudopolyarthrite rhizomélique, Facteur risque, Appareil circulatoire pathologie, Epidémiologie, Incidence, Etude cas témoin, Etude longitudinale, Chronique, Vaisseau sanguin pathologie, Vascularite, Maladie système, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Facteur risque cardiovasculaire
Mots-clés Pascal anglais : Giant cell arteritis, Elderly, Human, Pathogenesis, Polymyalgia rheumatica, Risk factor, Cardiovascular disease, Epidemiology, Incidence, Case control study, Follow up study, Chronic, Vascular disease, Vasculitis, Systemic disease, Diseases of the osteoarticular system, Inflammatory joint disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0017150
Code Inist : 002B07. Création : 31/05/1999.