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  1. Irritable bowel syndrome, gastro-oesophageal reflux, and bronchial hyper-responsiveness in the general population.

    Article - En anglais

    Background-Associations have been shown between irritable bowel syndrome (IBS) and gastro-oesophageal reflux, between gastro-oesophageal reflux and asthma, and more recently between IBS and bronchial hyper-responsiveness (BHR).

    Aims-To explore the inter-relations between these conditions.

    Subjects-A randomly selected community sample of 4432 adults.

    Methods-A validated postal symptom questionnaire investigating the associations between IBS, gastro-oesophageal reflux symptoms, and symptomatic BHR.


    3169 questionnaires (71.7% response) returned by 1451 men and 1718 women were analysed.

    One year prevalences, in men and women respectively, of IBS were 10.5% and 22.9%, of dyspepsia 26.3% and 25.25%, of gastro-oesophageal reflux symptoms 29.4% and 28.2%, of BHR 13.2% and 14.6%, and of chronic bronchitis 8.3% and 4.9%. Logistic regression showed independent associations between IBS and BHR, gastro-oesophageal reflux symptoms, and dyspepsia.

    There was no significant independent association between IBS and chronic bronchitis.

    In men and women the odds ratio with 95% confidence interval (CI) for IBS and gastro-oesophageal reflux symptoms was 2.6 (2.1-3.1 ; p<0.001) and for IBS and BHR 2.1 (1.7-2.7 ; p<0.001).

    These associations held on stratifying for sex and consultation behaviour.

    IBS, gastro-oesophageal reflux symptoms, and bronchial hyper-responsiveness occurred more frequently together than expected, 2.5% (95% CI 2.41-2. (...)

    Mots-clés Pascal : Côlon irritable, Incidence, Association morbide, Reflux gastrooesophagien, Asthme, Hypersensibilité, Bronche, Epidémiologie, Homme, Appareil digestif pathologie, Intestin pathologie, Oesophage pathologie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive

    Mots-clés Pascal anglais : Irritable bowel syndrome, Incidence, Concomitant disease, Gastroesophageal reflux, Asthma, Hypersensitivity, Bronchus, Epidemiology, Human, Digestive diseases, Intestinal disease, Esophageal disease, Respiratory disease, Obstructive pulmonary disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0016923

    Code Inist : 002B30A01A2. Création : 31/05/1999.